Evidence that positive selection drives Y-chromosome degeneration in Drosophila miranda
نویسندگان
چکیده
منابع مشابه
Muller's ratchet and the degeneration of the Drosophila miranda neo-Y chromosome.
Since its formation about 1.75 million years ago, the Drosophila miranda neo-Y chromosome has undergone a rapid process of degeneration, having lost approximately half of the genes that it originally contained. Using estimates of mutation rates and selection coefficients for loss-of-function mutations, we show that the high rate of accumulation of these mutations can largely be explained by Mul...
متن کاملNonrandom Gene Loss from the Drosophila miranda Neo-Y Chromosome
A lack of recombination leads to the degeneration of an evolving Y chromosome. However, it is not known whether gene loss is largely a random process and primarily driven by the order in which mutations occur or whether certain categories of genes are lost less quickly than others; the latter would imply that selection counteracts the degeneration of Y chromosomes to some extent. In this study,...
متن کاملPositive and purifying selection on the Drosophila Y chromosome.
Y chromosomes, with their reduced effective population size, lack of recombination, and male-limited transmission, present a unique collection of constraints for the operation of natural selection. Male-limited transmission may greatly increase the efficacy of selection for male-beneficial mutations, but the reduced effective size also inflates the role of random genetic drift. Together, these ...
متن کاملDegenerating Y chromosome of Drosophila miranda: a trap for retrotransposons.
In Drosophila miranda, the larval cuticle protein (Lcp) genes are located on the X2 and Y chromosomes, while in other Drosophila species the Lcp genes are inherited on the autosomes. We chose the D. miranda species as a model system to analyze the molecular bases of Y chromosome degeneration, a phenomenon observed in many species. DNA sequence analysis of the Y chromosomal Lcp gene locus reveal...
متن کاملEvidence that strong positive selection drives neofunctionalization in the tandemly duplicated polyhomeotic genes in Drosophila.
The polyhomeotic (ph) locus in Drosophila melanogaster consists of the two tandemly duplicated genes ph-d (distal) and ph-p (proximal). They code for transcriptional repressors belonging to the Polycomb group proteins, which regulate homeotic genes and hundreds of other loci. Although the duplication of ph occurred at least 25 million to 30 million years ago, both copies are very similar to eac...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2004
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng1347